Create a focal wall. Treat the powder room wall like a large blank canvas. If you fill up most of one wall with multiple artworks in a grid, the collection will have the visual impact of one larger piece.
Mix complementary finishes. Use a framed piece of artwork on one wall and carry the same tone to the other wall through more sculptural pieces.
Freshen with florals. Floral artwork can leave a bathroom feeling fresh and soft. Go large for a more powerful feel and pick up on the wall color for a soothing look.
Add a bright spot. If you have dark walls, bright artwork offers a stunning contrast.