No, no, no. If your kittens will be indoor only cats, there is no need to do the leukemia vaccine.

When I got my first kitten ~21 years ago, the leukemia vaccine was still fairly new, and a pretty big deal for vets to have in their arsenal of preventative medicine. We gave her, and the kitten we got a year later the vaccine, and continued to do so every year thereafter for 14-15 years, despite the fact that our cats lived indoors their entire lives and it was highly unlikely they would be exposed to the virus.

Our one cat developed fibrosarcoma (a vaccine-associated cancer) when she was 14 1/2 years old. The feline leukemia vaccine is very strongly suspected by many to be linked to fibrosarcoma.

Other adjuvented vaccines are often also somewhat suspect, but you need to weigh the benefits against the risks for each. Rabies, is usually required by many states (and is now given by many vets in the one year, non-adjuvented version).

Some people I know forgo the distemper booster (every 3 yrs, adjuvented type), others, including myself, opt to have it given. My feeling is this, leukemia exposure for my indoor cats is minimal (unless I bring home a leukemia postive cat or kitten, AND I believe, if the cat or kitten bites my cat). Distemper however, is airborne from what I understand, and therefore can be carried into my home (I volunteer one afternoon a week at an animal shelter), or, if my cat(s) needs to spend any time at the vet and another cat or kitten caged nearby has distemper, my cat(s) could theoretically contract it.

IMHO, and I have no veterinary background whatsoever, I would not give the leukemia vaccine to indoor cats.

I totally agree with cat mom, and I am a vet.

No indoor only cat should be vaccinated with FeLV. The risk of getting the disease is very low compared to the risk of vaccine-associated sarcoma for indoor kitties. Cats over 1 year old are very resistant to FeLV even when not vaccinated. The only situation where I would consider vaccinating a cat with FeLV is an outdoor kitten, or a kitten in a household where there are often new feline arrivals, such as someone who fosters often.