Good question. I found this, FWIW.

“For optimal stability and to prevent tilting, place two sawtooth hangers about one-quarter to one-third of the way in from each vertical edge of the frame. A common rule of thumb is to space them apart by roughly half the total width of the frame. For a 24-inch frame, for example, the hangers should be spaced 12 inches apart, placed 6 inches from each side.“

if you are using command, are they hook and loop... just use the accompanying piece and match them up when hanging.

Just wanted to add I really like those Command hooks for wall art.👍🏻