Amoeba Fusion aims to empower societies by providing a space for decentralized, innovative start-up communities. onE.GLobe considers the built environment a living, breathing, multiplying organism, evolving in nature with harmony. The structure can grow horizontally and vertically by adding new cores in different directions per each site condition. It creates public plazas shaded and shielded by the building as it grows. Fully self-sufficient structure houses flexible 3D printed dwellings and workspaces surrounded by semi-open garden spaces and atrium. Thirty feet deep floor plates receive daylight from the exterior and atrium and can conveniently be used as open-plan office space. Electrical, plumbing, and HVAC systems are distributed through modular floor plates, on which 3D printed modules are flexibly plugged in. 3D printed inflatable shells with indoor air cleaning plants house a plug-in kitchen, bedroom, workspace, and bathroom modules. The bridge-connected clusters have decentralized systems with the off-grid micro-grid integrating renewable energy sources and excess energy storage. Compact layouts provide space for an increasing number of entrepreneurs, making them socialize and inspire near their accommodation. Eliminating corridors in dwelling units with an efficient design and replacing them with the garden space surrounding units achieve this endeavor.