I've done a lot of grape hybridizing over the years. My greatest project is a cross of Muscadine x True Vitis. I will start with hybrids and cross back to hybrids, since the jump between species is a long one. It can be done, but only a few are fruitfull and most are sterile mules.

The Muscadines have by far the strongest disease resistance of the Vitis grown in America. Am also growing some Pluots from Seed, which are hybrids of plum an apricot. One cross I'd love to try is Salmon Berry x Raspberry.