Do be careful. I tried wiping with a damp cloth but sometimes it removes the colors from the print. Hope you find an answer.

Thank you for the warning ... I was afraid that might happen! It may seem foolish to put a lot of time & effort in a department store bought picture but my bedroom furniture is spanish style & this huge picture is a paper print of a painting (not of a real person) of a spanish lady with a lace mantilla, etc. & in a pretty big frame, , fits is nicely. From a distance it often is mistaken for a real painting! I shall not try anything until I get something safe to try ... thanks for your caution!

Years ago we used a wall paper cleaner on wall paper. It was a sorta a rubbery composition of some sort. Have no idea if it would work or is even available.

I found an old oil in the attic that my grandmother did...I looked on line and it said to take a very soft brush, like a shaving brush and use just that. I did and it cleaned the dust off nicely without doing any damage.