Wood moves with humidity. Nothing will really stop moisture migration. Back priming all sides of your backsplash will help. The problem with sheet goods is that the profile, the detail is not as pronounced as the real thing...You want the detail. So, back prime, construction adhesive and blocking to nail to.

Mahalo, that's were I was headed but just wanted to make sure I was on the right page! Wish me luck.

No worries! Good luck!