No to the mirrors and amuch better set of lamps bigger for sure one on each side of the bed that lamp on the dresser needs to find another home . Think about what you love in a 5 star hotel room and that is what should be in a guest room IMO.

I don't find that wall is missing anything without the mirrors but do you find the mirrors make the room feel brighter to you? Depending on who uses the bedroom, a lamp on both sides of the bed might be appreciated. I think it's Martha Stewart who advocates spending a night in a guest room to see how it feels and works. You might try that to help you tweak the elements.

I think the two mirrors and the two pieces over the bed would be too repetitive. I also think you could ditch the mirrors and try the over the bed pieces on that side wall, one on each side of the window. I don't think you need anything over the bed. Yes to two lamps, maybe glass or something lighter or even metallic. I'd also remove the foo foo light on the dresser in favor of nothing or something more simple, and take off the piece over the doorway. Maybe ditch the hamper as a guest wouldn't use it, and find a prettier garbage can and put where the hamper is now. Lastly, a floor lamp behind the chair would be appreciated by a guest who wants to read at night. Nice comfortable looking room!

The room feels calmer without anything on that wall.

Ditch the mirrors, flank the window with the two pieces over the bed (centered 5' above the floor,) replace both buffet style lamps and use these charts to get the overall height and the volume of the lamp correct for where they are and what they're with.