I think you're overthinking it. Ideally I'd place it around the foot of the bed so the bed doesn't become an obstacle, but I wouldn't design my house around it

Both of your options, as written, make it seem as if the entrance to bathroom, if off to the side, will be somewhere between the foot and the head of the bed; and if at the "front of the bed" will be smack dab in the middle of the space directly in front of the bed.

Our master suite has the entrance to the master bath on the side, but it's at the very end of the room. And, that's my side. 🙂 If my Hubs gets up during the night and heads that way, it doesn't disturb me because he doesn't walk past my side of the bed. As it turns out, though, the upstairs hall bath is just outside the doors to the master suite, on his side, so he heads that way if he gets up in the middle of the night. (We don't have kids or anyone else living here - it's just the two of us.)

Could you post your possible floor plans, so we can make a better judgment call, or offer other options?

Near the foot, off to the side. That way no one walks more than half-way around, no one can see it from the bed.

Why would you have to have the closet door straight ahead of the bed? I wish we had wall, then I could have art, or a tv. As it is it’s my bypass sliding closet doors.

I've never not bought a house, or not stayed at a hotel, because someone would have to walk around the bed to get to the bathroom!

It is better to have the toilet, bathtub, shower, and sink in the bedroom; but other factors influence the relationship and they usually end up in a separate room. That "room" has a myriad of factors that influence its location.