I would probably err on the side of left justify it since I am right handed. Depends on the door placements and other fixtures. I am a big fan of cardboard templates for such decisions.

Depends. I would prefer a larger, empty area top of a vanity space in a primary suite’s bathroom. Off center would work.

For a guest bathroom, I want a sink and room for hand soap pump and little else. Centered sink would be fine.

Does that help?

How small is small? If you are off-centering a sink because of drawers, I would do it away from the wall because of elbows, and because anything placed on the "extra counter" area would be in a corner and not on the free end of the vanity, so less likely to get knocked off.

Palimpsest makes good points, but I agree with Mtn because I, too, am right-handed so I would want my drawers on the right.

I am left handed and would want the drawers on the right so that the open counter end was next to the wall. FWIW, most left handed people easily adapt to the right hand world. In our last house, my things were left and right of my sink. Here, I only have drawers to the right. No big deal.

I would want the sink closer to the entry door however that works for the arrangment in the room.

Put the sink farther from the wallsoyou dont bash your elbows.

We had to do an offset sink when we did a minor re-do to our small bathroom at our lake place. There was really no choice (without re-routing plumbing which wasn’t possible) but to do the sink against the wall by the door. It is fine and we don’t bump elbows on anything. We have 3 nice drawers and an open space under the sink, plus a taller sink than previously. What I also did was to extend the granite slab about 3” further than the usual 1” or so. There is plenty of space between the cabinet and the toilet so it just adds some great counter space.

Mine is to the left with the wall in the right. Small bathroom, smaller vanity