Even with "weed block" and gravel you could see new "weeds" growing in that area. If this is going to be a pathway then some kind of stone, comfortable to walk on, would be a better choice but keep in mind that as time passes and dust and organic matter accumulate in the crevices between the stones "weed" seeds will also accumulate and will germinate and grow.

I agree with kimmsr. I have an old gravel mulch bed that has accumulated a ridiculous amount of organic matter (was that way even before we moved in) and it is a pin in the rearend now, to clean out all the gravel.

If you DO decide to go with gravel using a THICK hard plastic barrier will make any future maintenance/removal MUCH easier.

I use mulch and white vinegar.

Concrete works.

I have gravel. I am finding it terribly frustrating with all of the "grass" roots underneath that continuously sprout up more grass. Unfortunately this year, it went to seed. I pulled what I could out. Then watered regularily so as to make the seeds sprout this summer, then started spraying. I have been using Roundup. But it only works on the post emergent weeds/grass. I'm wondering what I could use to get the seeds. My goal is to try and decrease the amount of sproutings in the spring. HELP.

White vinegar? How do I do that? Now years later from my original post, I still have the same problem? Maybe mulch over the gravel, and how thick? And then where does the white vinegar come in??
Thanks

Vinegar, Acetic Acid, will kill plants when sprayed on them. I have seen instructions that say to dilute the Vinegar with water but that is not necessary, and which Vinegar (that meant to be put on a salad or pickling) can make a difference since 3 to 5 percent Acetic Acid is not nearly as good as 20 percent Acetic Acid.
However, the Vinegar kills only top growth so the plants roots could send up new growth that will need to be sprayed again.
There is nothing that will prevent Mother Nature from trying to grow plants where there are none since she feels bare ground is not good.