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New study: Roundup

21 years ago

Here is the abstract of a new study of Roundup.

____

Environmental health perspective

Differential effects of glyphosate and Roundup

on human placental cells and aromatase

Sophie Richard, Safa Moslemi, Herbert Sipahutar, Nora

Benachour, Gilles-Eric Seralini

doi:10.1289/ehp.7728 (available at http://dx.doi.org/)

Online 24 February 2005

Abstract Roundup is a glyphosate-based herbicide used worldwide including on most

genetically modified plants in which it can be tolerated. Its residues may thus enter the

food chain and glyphosate is found as a contaminant in rivers. Some agricultural workers using

glyphosate have pregnancy problems, but its mechanism of action in mammals is questioned. Here we

show that glyphosate is toxic on human placental JEG3 cells within 18 hr with concentrations

lower than the agricultural use, and this effect increases with concentration and time,

or in the presence of Roundup adjuvants. Surprisingly, Roundup is always more toxic than its

active ingredient. We tested its effect on aromatase with lower non-toxic concentrations, the

enzyme responsible for estrogen synthesis. The herbicide acts as an endocrine disruptor on

aromatase activity and mRNA levels, and glyphosate interacts within the active site of the purified

enzyme, but its effect is facilitated by Roundup formulation in microsomes or in cell culture. We

conclude that endocrine and toxic effects of Roundup and not only glyphosate can be observed in

mammals. We suggest that the presence of Roundup adjuvants enhances glyphosate

bioavailability and / or

bioaccumulation.

_____

Here is a link that might be useful: hormone disruption and fetal damage

Comments (14)

  • 21 years ago

    At least I'm wise enough to post this here instead of on Organic Gardening.

  • 21 years ago

    True. We might avoid the war of citations and abstracts. I've held back on the urge to post three abstracts. What a struggle of practicalities over principles!

  • 21 years ago

    Yes, what a conundrum. It's a situation worse than self-censoring material that might be construed as political or religious.

    Post those abstracts on this thread Marshall. I promise not to post innumerable cites, abstracts or secondary materials attempting to refute them.

  • 21 years ago

    I wont promise anything, but I would alos appreciate seeing those abstracts.

  • 21 years ago

    Here is another study showing negative effects on frog, brought to you via Prof. joe cummins.

    -------------------------------------------------------
    The current work comes on the heals of French work showing strong
    effects of the herbicide on animal reproduction after exposure to levels
    of herbicide on tenth the level recommended for spraying. Glyphosate
    should be re-evaluated by EPA at this time. However, the response from
    the regulators will likely be a pr campaign defending the pesticide
    rather than the frogs.

    Can the planet live after the frogs are all wiped out? We may be shocked
    at the impact of the end of frogs may have on the framework of life on
    the planet.

    Ecological Applications, 15(2), 2005, pp. 618Â627
    THE IMPACT OF INSECTICIDES AND HERBICIDES ON THE
    BIODIVERSITY AND PRODUCTIVITY OF AQUATIC COMMUNITIES

    RICK A. RELYEA1
    Department of Biological Sciences, 101 Clapp Hall, University of
    Pittsburgh, Pittsburgh, Pennsylvania 15260 USA

    Abstract. Pesticides constitute a major anthropogenic addition to
    natural communities.
    In aquatic communities, a great majority of pesticide impacts are
    determined from singlespecies
    experiments conducted under laboratory conditions. Although this is an
    essential
    protocol to rapidly identify the direct impacts of pesticides on
    organisms, it prevents an
    assessment of direct and indirect pesticide effects on organisms
    embedded in their natural
    ecological contexts. In this study, I examined the impact of four
    globally common pesticides
    (two insecticides, carbaryl [Sevin] and malathion; two herbicides,
    glyphosate [Roundup]
    and 2,4-D) on the biodiversity of aquatic communities containing algae
    and 25 species of
    animals.
    Species richness was reduced by 15% with Sevin, 30% with malathion, and
    22% with
    Roundup, whereas 2,4-D had no effect. Both insecticides reduced
    zooplankton diversity
    by eliminating cladocerans but not copepods (the latter increased in
    abundance). The insecticides
    also reduced the diversity and biomass of predatory insects and had an
    apparent
    indirect positive effect on several species of tadpoles, but had no
    effect on snails. The two
    herbicides had no effects on zooplankton, insect predators, or snails.
    Moreover, the herbicide
    2,4-D had no effect on tadpoles. However, Roundup completely eliminated
    two species of
    tadpoles and nearly exterminated a third species, resulting in a 70%
    decline in the species
    richness of tadpoles. This study represents one of the most extensive
    experimental investigations
    of pesticide effects on aquatic communities and offers a comprehensive
    perspective
    on the impacts of pesticides when nontarget organisms are examined under
    ecologically
    relevant conditions.

  • 21 years ago

    This press release states 07/03/05. Does this mean that we are able to look into the future or is there more than one convention (i.e. is it another way of stating 03/07/05?

    Here is a link that might be useful: link for above

  • 21 years ago

    I think there is already a warning on RoundUp saying it shouldn't be used in or around water. This latest study is confirmation of its danger to aquatic life. For some reason, some people have interpreted this to mean that there is no similar impact on land based communities.

    Henry, Europeans write dates in that order, for example, today is, 5 April 2005 (Marshall's Birthday). I read & posted that study on Organic Conversations. Good to see it posted here too.

  • 21 years ago

    Henry- common alternative convention in both US and Britain: day-month-year; probably more commonly used than the shuffled month-day-year. But the confusion caused is probably why the International convention uses year-month-day.

    Here is a link that might be useful: International standards (date)

  • 21 years ago

    the reason round up shouldnt be used near water is because it contains surfactants to help it adhere to the plant surface. the surfactants are bad for fish and particularly insects that cling to surface tension of water.... there is a glyphosphate product that is approved for use in and around water, its called Rodeo, commonly used to control overgrowth of underwater vegetation...

    not that i am a round-up fan, i just thought i would clarify why its bad for water.

    now there is a new round-up being advertised that includes weed suppression as well - advertised for up to 3 to 4 month control...i havent had a chance to look into that one... anyone know what the new ingredients are?...i am guessing similar to preen maybe?

  • 21 years ago

    Well I'm an organic gardener, but I couldn't survive without Roundup. My understand was that it turned itself into nontoxic chemicals after 24 hours or so. All I know is that here in South Carolina there is no way I could garden without using it. It's tropical down here.

  • 21 years ago

    No, Roundup (at least the formulations I have used) is neither so benign nor so short-lived although perhaps the active ingredient, glyphosate, is less impactful that the synergists and other ingredients. In years past I ran "field trials" with different ground-covers where Roundup was used to kill out bermuda grass and other noxious weeds before re-seeding or re-plugging. There was a good 6-month residual effect on most ground-covers. Revegetated spots took that long before appearing similar to the main cover. The spots untreated but revegetated at the same time took less than two months to fill in.

    I live, landscape, landscape manage, and organic farm in S.Cal., a lot more tropical than S.C. We learned to live without widespread use of Roundup and other pre- and post-emergent weeds through management practices. I admit to using Roundup on weeds coming up through paving and other difficult situations. We might even spray out a bermuda lawn (but none of the others) if clients insist because of costs. OTOH, the kill never gets all the stolons and does nothing about the vast store of bermuda grass seed in the soil profile.

  • 21 years ago

    In light of the opening article, and the article Henry posted, I'm assuming since aquatic life has an endocrine system which can be damaged by glyphosate, it isn't just the surfacant that is probelmatic. Endocrine damage isn't as immediatley dramatic to an observer as the sudden death of tadpoles noted in the study Marshall posted.

    I've never used RU, or any herbicide. I had no idea so many people did before I joined GWeb.

  • 21 years ago

    Roundup has been one of the most popular herbicides in the world as a general post-germination herbicide. Formulations of 2-4-DT are widely used as post-emergent herbicides for controlling broadleaf plants (dicots) in lawns and in maize.

  • 21 years ago

    Marshall,

    2-4-D and simular are widely used for "burndown" before sowing soybeans. While 2-4-D is probably more benign than most herbicides, I haven't forgotten the time the field adjacent to me was sprayed late in the day with almost no wind. This would seem good. However that night it vilotated [vaporized in part] and caused me some damage.

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