It'll look fine since it's a throw type spread. It would need to be at the edges, if you were making a fitted spread. If you have some extra fabric to play with, you might want to make a small sample and put it on your bed, so you can see how it'll look, before you make it all up and then decide you don't like the look.

I've seen piping that sat about 24" in from the edges of a spread and it looked fine....It did give a very blocky look...of a skinny strip, fat strip, skinny strip look. The girl did make some shams and that really made the overall look very nice. I think I'd try a small sample and see if you liked the look.