Evan, I'm from Beaufort but now live in Alabama! I'll bet that you don't want to swap.

Vegetable growing in a semi-tropical climate such as Beaufort requires special attention to timing. Please visit the local Extension Office for a copy of their vegetable planting guide as well as a list of suggested varieties for the area.

Find out how and when to collect soil samples for testing, too. Is your garden in a sandy location like much of the county? I FAR prefer my Alabama red clay..

I confess that I've never tried a 'three sisters' garden, since it never seemed practical for me so I can't advise you there. You can grow the same varieties nearly anywhere, though, once you have the timing for planting scheduled properly.

Evan, you may also wish to visit the Vegetable Gardening Forum and/or the Organic Gardening Forum for helpful answers and guidance.