I wouldn't lose any sleep over it. Scroll down to Pests and Potential Problems for a list of possible ailments. Whatever is affecting your Virginia creeper might make it look less attractive for a while, but only a freakish outlier would cause permanent damage. I grow the vine all over the place. Caterpillars have a field day munching on it. Birds rip out entire sections for nesting material. It always bounces back like a trooper. In fact, the only way I can inflict permanent damage is to whip out the loppers and pick axe.

You're right about it not causing permanent damage. It was affected last year and it came back wonderfully, sadly the disease came back too.

If maintaining a manicured appearance is important to you, you could remove the wilted leaves with loppers/pruning shears. If it is caused by some kind of blight, dispose of the removed leaves far away from your VC display.

Looks like leaf hopper damage, to me. The stippling and fecal matter deposits jump out to me immediately. Add to that the fact that Virginia Creeper is highly attractive to any leaf hopper that infests grape plants, some of which can destroy whole plants if unchecked.

Thank you so, so much, it is indeed leaf hopper damage.