Different substrates absorb paint at different rates. The spackle spots make for a different substrate vs. the unspackled wall. The result is the spackle spots are flashing.

You have to even out your substrate. Lightly sanding the spackled spots and a coat of primer over the entire area, then 2 new full coats is how I'd fix it.

Ok thanks. So it’s ok if I prime over the prior painted surface if I sand w 220?

Not the whole wall. Just hit the spackle spots to knock them down a little before prime and paint.