If you're set on the plan as is: for the three piece bathroom, move the tub to the long wall. Have the sink in a vanity facing the open door with the w.c. beside it, or preferably between the tub and wall. As is, there's no elbow room for the sink. Adjust the smaller bathroom so you don't open the door to face the w.c.

Starting from scratch: for privacy, bedrooms should be separated by other rooms or closets. Consider moving a shared bath between the two. The laundry room can be cut to half the size. Living space should take precedence over storage space.

I can't have a bathroom on the far right, it can't connect to the sewer line from back there. The laundry space is that large because of the support post, I don't see any point in having a wall a few feet from a post, most of that space would be functionally useless. I could potentially move the post a bit, which could allow that space to shrink.

The laundry space is that large because of the support post, I don't see any point in having a wall a few feet from a post,

The post can be in a closet. Certainly one is needed as you've chosen to omit closets from the bedrooms.

I can't have a bathroom on the far right, it can't connect to the sewer line from back there.

Consider a new sewer line connection. A sledge hammer and breaker bar is usually all you need. Ejector pumps can be used if necessary. I completed a new home in an area with shallow sewer mains and that's what we did.

What is a "2-1"?

Where is the "front" of the house?

2 Bed, 1 bath. Front is to the left in the drawings.

Hiring a local architect would be a good investment.

You’re describing a teardown and redo. Not a “remodel”. It will be cheaper in the end. With fewer restrictions.

I can't imagine this is cost effective. Regardless, I assume you had a structural engineer evaluate your home and tell you this needs to be done? Unreinforced brick is bad in seismic zones, but reinforced brick is still used. In 70 years your house has gone through a few earthquakes already...so is your foundation damaged?

Window emergency escape will dictate the bedrooms, so whereever those can go based on grade or wall construction, is where the bedrooms must go. If that's an egress door (by the stair), then you only need 1 other emergency escape.

Bedrooms should have closets, if possible best if they can be nearer the bathroom.

I see no reason for the Powder Room next to a Bathroom, unless the Bathroom is a Jack-n-Jill only for the bedrooms if they are placed there.

Is the garage to house a car if desired? That will increase size.

Hu,

I applaud your efforts to adapt an 80-year old home to fit your modern family's lifestyle. The scope of your project is pretty significant. Given the seismic and utility considerations, the design task has more than the usual number of design constraints.

There are a number of ways you can approach design. Drawing one yourself and crowd-sourcing design ideas here on houzz.com is one of them. I suggest that the most cost-efficient and time-efficient route to a design that appropriately balances all of the various constraints is to sit down with the engineer and an architect or talented residential designer to explore alternative concepts. It shouldn't take more than two hours, some tracing paper, and a pencil or two (or their more modern electronic equivalents.) That way you don't end up with a design that won't work because you need to cut into a shear panel to install an egress window in a bedroom or won't meet code requirements or that never considered a neat alternative that's germinating in the brain of folks who are trained to translate your needs into something really special.