I had all knobs in my old home that I sold 1 1/2 years ago and now I have all pulls. I wanted something fresh for my kitchen. I did all 6 5/8" pulls, even on 36" drawers that were about $20 apiece.

Pulls are easier on arthritic or older hands.

I have knobs on all my cabinets and 36 inch drawers. The drawers have 2 knobs each. My last house was all handles. I had/have no problem opening either. The one thing I do notice is the cabinet say cleaner and less fingernail scratches around the knobs vs around the handles due to the way you use them. I have handles at camp and would of preferred knobs.

I have all knobs. I have much bigger drawers than those shown and accidentally installed a single knob in them and there is no problem using them. I did not save money buy using knobs (but I did save money by drilling one hole instead of two! OOps.).

Some knobs may be challenging for bad joints but it depends on the shape of the knob. Mine are easy and not functionally that different from a (small) pull except that they are easier to grab than a pull because you can come at them from any direction. The ones you show might be hard to get a good grip on for really heavy drawers. Might be fine!! test a knob before you buy a ton.

You could do knobs on the uppers and pulls on the lowers. The problem with two knobs (or two pulls) on wider drawers is that people tend to pull on just one, and that could result in the drawer racking over time, and/or the knob or pull that is used the most loosening in its hole.

Your statement "I’d about 20 ~$100 pulls for those large drawers" - whaa? are those pulls made of gold? A 36" drawer should have a 12" pull (the rough rule of thumb is the pull is 1/3 width of drawer). My pulls are Top Knobs Princetonian pulls. I like them because they come in a bunch of sizes and several finishes, are clean-lined, and most of all, they are not so shallow which means you can get your fingers into the pull nicely. The 11-11/32" size is $15-16. There are a ton of pulls in that price range, not $100 per pull.

When I had my kitchen renovated a few years ago, friends and family suggested to get all pulls; especially on the below counter drawers and cabinets. They said pulls can get caught on your belt loops, pockets and vacuum cords. I chose simple 5.5” Top Knob pulls for my entire kitchen. I am still happy with my choice. Hardware choices in a kitchen is a personal decision, like choosing jewelry for your outfit! Best of luck in your journey.

You could do knobs on the upper cabinets and pulls on the base cabinets. Or knobs on the doors and pulls on the drawers.

I like knobs on cabinets and pulls on drawers. I caught my hand in a cabinet pull too many times in my old kitchen,

If you do pulls, make sure they don't end up looking like old-school filing cabinets and tanker desks. :)