I would use one size pull for all drawers. It'll look messy using two sizes.

Answer: it depends. Personal preference also comes into play.

It depends on the size of kitchen, layout of kitchen and how many of each of the two different sized drawers stacks you have. You might not see every pull from every angle, specially if you have an island blocking sight lines.

I have 3 sizes of pulls, but I have a large kitchen and a larger difference in the width of the drawer stacks. I used knobs for the cabinet doors. Definitely doesn't look messy!

I used two different lengths of the same pull. On the smaller drawers, I used 4-inch center-to-center (6-inch end-to-end), with 6-inch center-to-center on the wider drawers. I used knobs on the small drawers on my island/cart.

Dealer's choice. Total opinion.

The link below has good info on kitchen cabinet pulls and knobs:

https://sandiegohardware.com/blogs/resources/the-ultimate-guide-for-cabinet-hardware-placement-and-sizing