Today’s skyscrapers do not accommodate ever-changing uses, health, and energy crisis. onE.GLobe proposes organically grown, flexible, and scalable live-work-play structures which can adapt to any condition. Stress increases the risk of chronic diseases, the leading cause of death and disability with around 75% (Source 1a, 1b). Improving human health through a thoughtfully designed environment is as important as energy conservation and carbon sequestration. We can also address all three goals with similar solutions, such as allocating large green areas, water features, and diverse uses in proximity. Nature makes people happier and healthier, and it also absorbs stormwater and can be used for renewable energy production. Therefore, we can achieve resiliency for both environment and society easily together. Amoeba Fusion aims to empower societies by providing a space for decentralized, innovative start-up communities. onE.GLobe considers the built environment a living, breathing, multiplying organism, evolving in nature with harmony. The structure can grow horizontally and vertically by adding new cores in different directions per each site condition. It creates public plazas shaded and shielded by the building as it grows. Fully self-sufficient structure houses flexible 3D printed dwellings and workspaces surrounded by semi-open garden spaces and atrium. Thirty feet deep floor plates receive daylight from the exterior and atrium and can conveniently be used as open-plan office space. Electrical, plumbing, and HVAC systems are distributed through modular floor plates, on which 3D printed modules are flexibly plugged in. 3D printed inflatable shells with indoor air cleaning plants house a plug-in kitchen, bedroom, workspace, and bathroom modules. The bridge-connected clusters have decentralized systems with the off-grid micro-grid integrating renewable energy sources and excess energy storage. Compact layouts provide space for an increasing number of entrepreneurs, making them socialize and inspire near their accommodation. Eliminating corridors in dwelling units with an efficient design and replacing them with the garden space surrounding units achieve this endeavor. Amoeba Fusion New York is located at a General Commercial Zoning district in NYC with residential and commercial uses. The site currently accommodates six towers. This project explores a more resilient design solution for an innovative, diverse community for the post-pandemic world. Located in the Lincoln Square neighborhood in Manhattan, bordering Hell’s Kitchen with countless restaurants, the site is close to various public transportation, universities, cultural spaces, and businesses, making it ideal for an innovative, creative crowd. Mixed-use commercial and residential buildings are allowed with a floor area bonus of 20% with a public plaza. With tower regulation, there is no minimum lot coverage requirement, and no rule regarding the distribution of floor area allows the tallest buildings in the city. There are plenty of luxury residential buildings in New York City, but they don’t serve innovative young people and entrepreneurs. Co-living buildings do not provide proper workspaces within the facility. For these reasons, onE.GLobe aims to investigate ways to design long-term live-work-play environments for innovative young people and ease the effects of the future pandemics with its efficient, flexible dwelling units and workspaces surrounded by semi-open garden spaces, atrium, rooftops, public plazas, and wet ponds.