Our Marcie did the same. We bottle fed this kitten since she was about a week old and she's now almost 6 months old.
The spray bottle helped her NOT to go on the kitchen counters but did nothing as far as her aggressive behaviour toward the other cats or people.

Ya know what worked for us? You know that little short Purrrrrrrr? sound cats will make to one another as they greet? I did that to Marcie and *instantly* it was like she knew she was a demon child and needed to stop. Now when she runs up to anyone, she makes that happy purrrrr! sound. She does it to the other cats and the dogs and if she seems too aggressive in her play ... a quickie reminder with that sound and she snaps back to nice kitty mode. LOL!

Hope that helps.

Thanks I will try that. Ernie does that, maybe thats why she plays with him and just attacks the other two. She seems to have a vendetta against miss Calie like she is keeping a watch out so she can run and attack if Calie ventures out from undernieth the bed. The squirt bottle only stops her for a moment, then shes right back at it.
Funny since I have been typing this Emma came up to me and did the little purr thing.....and yup she just did it with Ernie.....hhhuuummmmmm I wonder if this is a carry over from their days outside as strays. Calie had been roaming all summer, Emma was a dump off and just showed up one day, maybe they had "words" then?