I was thinking of going with all arched handles. No knobs. My current kitchen has all knobs. I am always catching clothing and my purse strap on them. My goal this time is to eliminate anything that catches. Ikea has a reasonably priced really large arched handle that I am considering.

There are at least 2 ways to think about this. Either the handles are jewelry, or you don't really want to focus on them and let the cabinets shine on their own. That is a very personal choice.

As far as utility, you can use the same style handle in different sizes to go with the different size drawers. I personally love the look of all horizontal handles if the kitchen has a modern feel.

Note how they used 2 shorter handles for the wider drawer

Contemporary Kitchen · More Info

and another

Contemporary Townhouse Kitchen · More Info

I think it can work for mission style. Are the cabinets installed? You can wait to put the handles on last and order some samples to try things out. I would even wrap pens or dowels in aluminum foil using the lengths you are thinking of and taping them to the cabinets to see the general size effect. 40+ handles is a lot of $ to get something you don't like

Do you know if you want chrome or oil rubbed bronze? I think start there, and then see what you can find that you like. ORB knobs on darker cabinets will blend into the color of the cabinets - but that maybe a look you like:

Note how the knobs and handles are pretty invisible on the back wall

Leesburg Traditional Kitchen - Island · More Info

I was thinking brushed nickel because that's what I have for the faucet and i prefer a stainless steel sink. This is what caught my eye. Thanks for the pictures. 2 handles on drawers makes sense. http://m.homedepot.com/p/Richelieu-Hardware-Brushed-Nickel-256mm-Contemporary-and-Modern-Pull-BP871256195/202213220

Those are nice. I like that they're arched to the cabinet, nothing sticking out to catch on your clothes. And I see they come in a couple of sizes so you can stick them on the smaller pullouts. I'm not a pro in any kitchen stuff but I can pull lots of picture examples which I think help this sort of decision process.

Get some samples, and use 2-sided tape to stick them to the doors/drawers (if the handles aren't too big).

I love the look of horizontal pulls too - but when I mocked up MY pulls on MY doors, it didn't look as good as vertical on the doors.

There really aren't any wrong answers here. Go with what you like best, and what fits in your budget. One long pull costs more than twice as much as two smaller ones for a wide drawer.

I don't think I've ever seen a kitchen reveal where I thought "Boy, that would sure be a terrific-looking kitchen, if they hadn't messed up on the pulls/knobs!"

A very insightful comment on the thread what makes kitchen's easy to clean/ keep clean http://ths.gardenweb.com/discussions/2816391/what-makes-a-kitchen-easy-to-clean-easy?n=38 referred a minimum distance between the handle and the cabinet surface.

From personal experience in a white kitchen, I can second that.