Do you happen to have any pictures?

As for the affected bed, what is different in the soil (growing mix) that's not in the other(s)? Perhaps manure, composted or not? Or a different kind of organic matter, commercially bagged or not?

If any of those, look at this re herbicide carryover:

http://smallfarms.oregonstate.edu/sfn/f09Herbicide

Does the picture on that page match what you are calling "The leaves turned inside out"?

Hi, unfortunately I don't have any pictures. Some of the leaves curled upwards but really the rest of the plant looked fine using my untrained eye. It just never produced any fruit. I can't tell from that pic you posted if its the same thing. Same bed, same soil, different plant two years in a row. I will say that I used the same exact soil makeup in all three of my beds. Which was basically a combination of peat and mushroom soil.

I'm planning to clean out all 3 raised beds and start fresh this year with new soil. My raised beds are about 12 inches deep. do I need to dig down deeper into the earth soil? Am thinking this disease probably spread? Without knowing exactly what is is hard to say for sure. Maybe best to be safe?