Why don't you add your general location/growing zone to your name as others do? It is much easier to give more suitable advice...

Fast drainage is great. in any locale. How do you know 'soil' is dry?

If you watered thoroughly until the water runs out of the container holes then I bet just the top of the soil is dry and it's still wet down below. Can you get a wooden skewer / chopstick to stick in the soil (careful of the roots of course)? This will give you a much more accurate reading of the soil moisture.

50/50 should not be drying out in 1 day, that is unlikely unless you have a teeny tiny container. Quick draining and quick drying is a good thing, you already know that though, you added perlite! I do not feel 50/50 is too perlite heavy.

Do you have a specific plant in question and if so, can you post a picture?

I'm in a growing zone 4, I believe, but these are all indoor plants.

I have a wide range of plants; crassula, echiveria, aeonium, sedum, graptopetalum. They don't necessarily show any signs of being unhappy yet; it's only been a few weeks since I switched the potting mix. I'll give the skewer trick a try and see what comes up. I am not currently watering until it runs out the bottom, though.

Fast drying soil is not necessarily bad most times its good.

You didn't say they are grown indoors either :) Giving some more details (like a growing zone or growing conditions: indoors, under lights, how hot it is there and so on) and type of plants helps. Otherwise we are just guessing...

Most ppl using soil in their mix seems to be happy with 50/50 and it doesn't dry up in a day. Many of us use very gritty mix, with little or no soil at all, and plants even outdoors do not need to be watered daily (unless you were using it in very hot, dry climate). Fast draining mix is the best, different substrates will hold some water that is enough for few days. When watering, succulents should be watered thoroughly and then again only when mix is almost completely dry. Indoors, it could be easily a week.