Usually, when a cat pees outside the box, it is due to stress inside, or outside, the household. How long has this been going on? Are there any other animals in the home, have you changed the cat litter recently, and is the litter box in an easily accessible (and quiet) place for the cat. Stress can come from outside the home if there are outdoor cats hanging around your house or peeing near windows and doors of your home.

It's also possible she's having side effects from the prednisolone. How bad is her IBS, how long has she had it, and did your vet try other options before using the pred? Has she been checked for diabetes?

Here is a good article with current info on cats with IBS. I deal with a cat that has IBS and so far we're able to controll it with diet and probiotics.

It has been going on for about a year. Her litterbox is in a spare bedroom, under a desk almost like a cave, perfect place. It started with the suitcases, our packing to leave. No other cats in the neighborhood; coyotes and traffic take care of that. We have not changed the litter, but I don't think it's a litterbox issue, rather a stress issue. This morning DH set up 3 Christmas inflatables and a full-size singing, dancing Santa in the house (another topic for that), and she has peed twice on the bed. Bed laundry done, kitty locked in a quiet bedroom with heating pad, litterbox, food. We have company coming.

When the vet put her on the pred, she was throwing up about once a day. We also started with a special food (Royal Canin rabbit), which she ate at first then started to refuse, then even refuse her usual Maxx cat, so now she's on Fancy Feast which she is eating along with Maxx kibble. I know it's not top quality food but she's skin and bones so we're happy with anything she'll eat. She doesn't throw up at all now except recently when she ate a piece of plastic Christmas tree.

Thank you for the link about IBS. She takes a pred every other day, about 6 months now. Blood work in June, would it be the BUN/Creatinine/Ratio numbers? If so, they are all in the normal range, actually the blood work was fine, no urinary infection either. No other options were tried. I'm going to see if I can find her blood work for kidney info. She hasn't gained an ounce on the pred.

Here she is, 3" wide and 3' long. Don't tell me she's a pretty girl because I'm really mad at her now! LOL....

Sorry if this all TMI. We have a very small house and I don't want it to smell like CAT! Guests coming today and next weekend too. I'm stressed; maybe can try some of that Zylkene myself.

Thanks Salti and Ann. To the vet ASAP.

Did she ever have diahrrea? I'm kinda surprised she was put on pred if throwing up was the only symptom. There are some quality store brand foods that have rabbit as the main ingredient and two that I have used are Natures Variety Instinct and Simply Nourish. My cats are picky about their wet food, and like yours, loves Fancy Feast but will readily eat the 2 brands I mentioned in the dry form.

Another product I swear by is this. I buy only the Feliway by Ceva since I find it works best with my cats for any stressful events. I would suggest you put one in your bedroom and another in the main living area. Also, I would place a second littler box in your bedroom or another room she has access to. At the same time, try a new litter (unscented) and see if litter box location and litter make a difference. After reading what hubby has done for Christmas I can see why she's a little stressed! I would be too! ;)

For the pee on your comforter I doubt washing and the NM treatment is completely removing the odor. People seem to be happy with Fizzion, a product that is promoted by Jackson Galaxy, and I think it will help eliminate any residual pee odors in your home. As long as she smells pee in an area, she will return to it.

As for tests.....Diabetes is a separate test from all basic blood work.

Personally, if vomiting and peeing were her only symptoms I would talk to the vet about weaning her off the pred, starting her on some probiotics, and offering some rabbit dry food in addition to the Fancy Feast. Since she didn't like the prescription diet, let the vet know you'll find a store brand that has similar ingredients. I would also ask him about the possibility she has reflux issues vs IBS. My dog used to throw up daily when he was eating Blue Dog Food but when I changed his diet all vomiting disappeared. He now takes a pepcid daily but that's his only med for stomach issues.

If you don't like what you hear from your vet, don't hesitate to get a second opinion or visit a cat-only vet.

Agree with above comment, are you seeing a feline, cat-only, vet? https://catfriendly.com/find-a-veterinarian/

http://news.vet.tufts.edu/2016/12/feeding-the-cat-with-flutd/

Does your cat have inflammatory bowel disease (IBD) or do you actually mean that she's been diagnosed with IBS (irritable bowel syndrome)? These are entirely different conditions. How was the condition diagnosed? Did you have an ultrasound, and were biopsies taken for a diagnosis?

Prednisolone is an appropriate treatment for IBD in cats. IBD does not always involve diarrhea, sometimes it's just occasional vomiting.... IBS is an entirely different disease than IBD, and presdisolone is not used to treat IBS. IBS would be a diagnosis of exclusion that you could only arrive at after ruling out everything else, including IBD.

You need a minimum of two big litter boxes for your cat. Get large sweater boxes or large rubbermaid tubs. Large. Try Dr. Elsey's Cat Attract litter (available on chewy.com, Amazon, etc.). Many cats prefer to defecate and urinate in different boxes. Get a third large sweater box and line it with kennel pads (pee pee pads), to see if she would like that. Many cats who are having inappropriate urination seem to like to use kennel pads to urinate on. You can sprinkle the kennel pads with cat attract sprinkles (different than the cat attract litter). Scoop the boxes twice daily and scrub every couple of weeks with blue dawn (rinse really well). Put the boxes where she would like them, not where it's good for you. Better to have a box in the living room (for example), if she wants it there, vs having her go outside of the box

I recommend a product called zero odor (you can get it at bed bath and beyond) to help get rid of the urine odor. It's really important to clean thoroughly and then use something like this to totally get rid of the odor, so she can no longer smell it.

Feliway diffusers can help with stress.

If your haven't done this yet, I think you need a full bloodwork panel...cbc, serum chemistry, T4, urinalysis, and a urine culture.

I'd revisit her diet and try to get her back onto the royal canin canned rabbit. Your veterinarian should be able to give suggestions to do this. They can prescribe an appetite stimulant (mirtazapine) to help her appetite and to help her transition to the new food.

I'd minimize stress and changes in the home, keep all laundry and suitcases, etc. (targets) picked up, make sure she's got plenty of cat towers (cats like to be up high), beds and hiding places.

You don't need a feline specialist or a cat only clinic. You just need a veterinarian who is into cats and feline medicine.

Socks, no advice, just commiseration. I have a very challenging dog and it's been a rocky road with him. There's been many times when I want to gulp down his Prozac.

LOL, Nanny! Actually the dog has peed on the floor near the bed where Daisy pees. I keep a sharp eye on the dog now to nip that one in the bud! Have you thought of putting a wrap on him? I did it for a while, but it's a nuisance. Not sure it really helps.

Sincerely, I thank you for ALL your great ideas. I will definitely enact some of them, ask the vet about diabetes and if pred is making her nervous.

Veggie--sorry I didn't realize there was IBS/IBD. Whatever....it was just diagnosed by the vomiting, blood and urine tests which were ok. They offered me some other pricey test which I said "no" to.

We have used our local cat specialist and won't go back there.

We put Daisy in another bedroom yesterday with her litterbox, food, heating pad, and she was quite content all day. Grandkids went in and brushed her, and she loved that. She has many perches and high places to jump up. Furniture as well as cat perches.

Oh, as for the laundry, Natures Miracle has a laundry booster which I used. Maybe not as good as Frizzle but the best I can do for now. Maybe a good soak in Biz wouldn't hurt.

Anyway.....thanks again, friends.

Socks, fortunately indoor accidents are not one of his many issues, so no icky wrap needed. I’m glad that you managed to keep Daisy from hijacking Christmas!