I think it depends on your guests' needs.

If I am staying a night or two or three, I will just live out of my suitcase, and won't need the dresser.

If I staying a month, I would unpack and use the dresser.

It is rare that I need a desk. If I need to use a computer for few minutes, I just open my laptop and sit on the bed. If I need my computer all day, I would appreciate the desk.

I agree with kempek01, and add that I wouldn’t put the bed in the corner. Keep two nightstands, even if they need to be very small, and maintain access to both sides of the bed.

What sort of guests? How long are you having guests???? If a guest is present for a weekend/holiday chances are they will live out of their suitcase so a dresser is not needed but a raised surface where they can place their suitcase would be most appreciated. No drawers aren't needed at all. Bedside tables for a book/kleenex/glass of water is NEEDED. Do your guests really care to open and use your closets? I have over the door hooks on the outside of my closet doors for use if a guest wants to hang something--but rarely is that a thing. If this is an Airbnb where people might stay for longer than a few days~that's a different question. In my guestrooms I have provided a chair/flat surface for suitcases/mirror/ability to hang things/bed. Guests want to feel there is room for their stuff at the ready--so MINIMAL decor cluttering things up on flat surfaces is appreciated. The desk need I don't GET. Why?? The flat surface to place their toiletries on/phone charger etc. maybe, but they aren't going to USE a desk. Any guest beyond a few nights is a boarder and that's a different requirement.

For a guest bedroom, it's essential to prioritize comfort and functionality while ensuring the space doesn't feel crowded. Between options 1 and 2, I would recommend option 1 for the following reasons:

1. A queen bed in the middle with a nightstand on each side provides symmetry and is more visually appealing. It also allows guests to easily access both sides of the bed.
2. A single chest drawer or a desk is sufficient for a guest bedroom. Since the room has a built-in closet, you can opt for a desk to offer a workspace for your guests. Alternatively, if you expect your guests to primarily use the room for sleeping, a chest drawer may be more appropriate.

Help me:

You HAVE a designer........yes?

https://www.houzz.com/discussions/6356479/interior-designers-do-you-expect-clients-to-procure-from-you#28375058

So I shall ask:

Where is the scale drawing of this guest bedroom? What furniture has been planned in that space?

How often will you have a guest, who will the guest be, will the room be used for any purpose other than a guest, how long is that guest likely to stay?

Are you questioning what the designer has planned? You don't like it?

This is what I referred to just moments ago on the other thread. A relationship with the person you hired. The moments when you discuss need, how you will use the space.How you want it to look.

Nobody here can even hazard a guess. there is no drawing of the space. Where are the windows? The entry door.....what chest, what size. All of the above. This is why one gets a designer.

The key thing is if the room is for two guests both people need to be able to get out of bed, both people need a light by the side of their bed, both people need a surface to set down a drink, a book, glasses, medications on their side of the bed. So two nightstands.

The nightstands could have drawers in them if people want to unpack some things.

For people who do not fully unpack, a flat surface for suitcases. Or foldable luggage racks will help. That could be a low chest or a desk with drawers. You don't really need a desk for a desk but one nice thing about a desk is that it has a spot for an upright chair that can be tucked into the kneespace.

Many hotels I have stayed in, especially older traditional ones had a desk like piece with drawers large enough to put clothes and a flat surface for a suitcase.

FIRST think about furniture choices before layout is figured out and consider multi- functional pieces that aren’t necessarily sets (more dynamic and casual). Think big picture re the feel/look you want before purchasing, including bedding, if you haven’t already.

A desk (+charger) can also work as a bedside table (+lamp) and a vanity (+small make up mirror).

Use a small nightstand/lamp on other side as a large surface is not needed.

A bench at bottom of bed is handy for suitcase if person doesn’t unpack or for sitting on.

A piece that provides a feasible surface and storage and I don’t think you need anything more unless you want to add a comfy chair.

I have 2 bedrooms in my home that are 12 x 16 with Queen sized beds.

Below is how I arranged the furniture I had in each room.

You should have plenty of space for a queen size bed, desk, dresser and 2 nightstands.