Primarily for heating,yes. Primarily for cooling or 50/50 heat and cool,absolutly not.

There's no reason you can't be comfortable in a room with a floor-mounted mini-split heat pump indoor unit. The unit doesn't rely on natural convection; it has a fan to circulate air. It would perform in a similar fashion to the PTAC units used in many motel/hotels, but with higher efficiency. You will need to consider your furniture placement in the room--as you would with any forced-air system.