Sure. Many do it. You just have to drain the thawed tomatoes really well first. Taste difference? No, but a little softer texture given the way freezing works to break down the cell walls.

Dave

If you haven't peeled them yet(I toss them in the freezer whole, unpeeled), do it when they're still a bit frozen...it's easier.

And be sure to drain them in a colander over a bowl so you can use the thin tomato juice for soup base or just to drink!

Deanna

You will notice a big difference if you try to make a fresh salsa. Think about using a can of diced tomatoes to make a fresh salsa - using the frozen tomatoes will be similar. But a cooked and processed salsa - the difference will be minimal.