I have used cypro but not mirtazapine. I do know that they are dosed completely differently, though. I also would space them (and any other meds) two hours apart from the Pepcid so that the Pepcid doesn't interfere with absorption.

Neither cypro nor mirtazapine work on all cats. You may find that one works for your girl but the other doesn't. It'll be trial and error to find out which has the desired effect and at what dosage. I will caution you to start with a very low dose of either one, though. The recommended dosages of each have been associated with some rather nasty side effects in some cats. The safest approach is to start with one at a very low dose, then increase, if necessary, until you either reach an effective dose or start experiencing unpleasant side effects. If the unpleasant side effects occur first, then it would be prudent to stop that drug and try the other one at a low (and potentially increasing) dose to see how she does on that one. I, personally, would start with cypro, since it seems to have fewer and less potentially severe side effects than mirtazapine.

You can read about dosing recommendations for both drugs at the following link:

Here is a link that might be useful: appetite stimulants and other appetite strategies

Hi Laurie! (I remember you helping me about 3 yrs ago when my old kitty was end-stage CRF....I certainly didn't expect to have to play nurse with a kitty again so soon).

Thanks for the info. I've already read that site and the archives here. I think whichever I try, I'll use even less than the vet recommends. I'm still undecided as yet another vet (that makes 3) said they'd try mirtazapine first.

I'm changing vets and taking Ellie in tomorrow (Sat.) to the new one for a B12 shot. I'll also ask about some more natural appetite stimulants, too. This new practice is only 2 miles further away (yea!) and also utilizes holistic practices. I think with long-term, chronic care, this is essential.

I like the Yahoo FIP group, but for more "general" cat questions, I still like to come here since it was "home" for many months while I dealt with old Casey's issues (and learning to sub-q her, etc.).

Thanks again,
Tracey