If you mean you want to change it so all four lights work on the same set of 4-way/3-way switches, the answer is no. The problem is you're short a conductor between switch A and B. You'd need two travellers, the neutral for the luminere #1, AND a return switched hot to feed the string of lights marked #2.

Nor can you restore the functioning of the way it was originally, as you are missing the power feed needed for the A/B-#1 switching.

You could make a very funky operating circuit if you replace the left hand switch in box B (I'll call it B-LEFT) with a four way connected to the travellers from box C (and on to box A). Though depending on switch configuration, turning on lights #2 will turn off light #1 (as I said funky).

You may find it easier just to figure out why the panel-to-B circuit isn't working. Are you sure you've checked all the breakers? It's not prohibited in this instance that the #1 lighting and #2 lighting be on the same breaker.

Thanks, for the response. I've spent hours trying to figure out why the panel to B went dead, it looks like I may need to start cutting some drywall.....

I'd start by looking at the end points (in the panel and in the switch box) before I start into the drywall.