what is the width of the wall, the width of the trim of the window and the distance from the trim to the end of the wall?

The entire width of the wall = 155 in (see how this is broken down on my diagram)

Width of window casing = 3.5 in

Distance from end of trim to window (on my diagram my window is also broken out)

To the left (larger space) = 66 in

To the right = 31.75 in

To me I wouldn't do the frames above each other since you have only have one window which is offsetted.

Thanks for the input

Chroma- Interesting 4"- that seems like a huge gap between frames? It is larger than my 3.5" window casings; that doesn't concern you from a design standpoint?

I am now reconsidering (since posting) and am looking at doing the square(s) under the window as one large box instead of two smaller ones. I actually taped this out on the wall and like the look of this. If this is the case, would it be better to consider the two left frames as independent (i.e./symmetrical, a pair), or should I match the two ends to the same width?

Thanks so much for the help!

being in the room is so much easier than calling it from the computer, but my first and last thought was that the moulding should highlight the window so I am thinking same moulding on either side of window and make the window the focal point of the wall and the remainder of the wall just trim out and make the lower ones all the same, small squares, or consider doing the lower to match the upper panels.....I think to me the panels are designed to add focus to a window, door, fireplace. But that is just me and is only my opinion.

"Interesting 4"- that seems like a huge gap between frames? It is larger than my 3.5" window casings; that doesn't concern you from a design standpoint?"

No, it does not seem like a huge gap to me. More to your point, it is not a problem that the gap would be greater than the width of your window casing. Do a photo search here for picture frame molding. You'll see many excellent examples where the gap is clearly larger. You'll also see some very good rooms where the gap is under four. So if you're more comfortable with 3.5", the trim police will not come knocking on your door.

" I am now reconsidering (since posting) and am looking at doing the square(s) under the window as one large box instead of two smaller ones."

The best advise I can give to this point is whatever you place above, should be mirrored below.

Lastly, calculate the size of the frame outs of the two adjacent walls. Those calculations will give some guidance how to treat your challenging window wall.

Thanks everyone!

We went with 4" stiles/spaces between the moldings based on the advice here (and we taped out the options and 4" made the most sense visually. We did a large box beneath the window (instead of 2) to mirror the window (a large box itself), and 2 equal size boxes to the LEFT of the window (instead of mirroring the ends)- the room is small enough where you won't necessarily stand back and see this wall head on, and there will be a table in front, so this seemed to make the most sense.