Will need a support of some size to climb on.

Of course. I was thinking about using it along a fence.

The question is, Do i put it in the middle of where I want it to be and let it spread, or does it grow along a central vine, in which case, i would plant it at one end.

Does that question make sense?

You could get either to work. Main thing is support of adequate size and strength, in combination with effective pruning and training - there will be no "letting it spread" on a fence, without ending up with it all heaped on the top.

If it's able to get a hold on the fence and stay attached to it.