Large tiles in small floors can have very weird looks because there are so few seams. They can look lopsided if not planned out exactly, and that often results in extra cost for extra tile, more wastage, more labor. And all for what? A mud room? Laundry? Bathroom?

depends on the tile, the room, and the look.

what are we talking about here? post pics and decide what you want.

remember, flooring is for a very long time. it's not the place to cut corners or save a few hundred. you can find plenty of 12x24 or even 24x24 for the same price as a 12x12