We’re going to need some photos of the room if you want help

Where is the door? Windows? Closet? Can‘t tell from these tight pics. A floor You’re asking about furniture and arranging, so knowing the room schematics is important.

This is all the usable space in the room

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The windows are a sliding glass door behind the shades and the closet is behind the doors.

Is this a guest bedroom or used nightly? Is the closet packed full or have room for the ironing board and multiple hampers?

It looks like the slider opens from left to right. Create an L-shaped work space to the right of the slider with one leg of the L starting in the corner and on that wall and the other leg of the L extending into the room with enough space behind it for the desk chair comfortably in front of the window facing out. Leave enough room at the end of that L to access the door. Move the bed away from the slider for more room. If the slider opens from right to left, reverse the floor plan of the desk.

The bedroom is used regularly and does’t have space for the ironing board or hampers.

The ironing board could be replaced with one that hangs on the door or a wall mount that just folds down in place.

Maybe the hampers and basket can be replaced with a single hamper with removable compartments insde that can be used as laundry baskets..

What's in the closet? Can you put the hampers in the closet? If the closet is a disaster, you aren't alone. Spend some time organizing and purging and use all of the vertical space. Unless you never have a couple visiting, I wouldn't get rid of the queen sized bed. A full isn't really comfortable for two people. Hotels have gotten rid of most of their fulls because of this. If the desk isn't big enough for the type of work you do, get a larger one. Laptops are less expensive than they used to be so maybe that would work for you.

IMO start with a sofa bed. Use the closet for all the computer stuff you can do wireless. I got a mini Mac I love it My hubby only likes PCs but maybe expalin why you need both are there 2 people using the office? I see no reason for a laundry hamper of any kind in that space . I like an office space to be able to be at least put away and guests only need a small space in the closet . I would do a desk type surface along that wall maybe 2 x as long with a low dresser on one end for paper and all the office stuff you need to have. If you post the to scale floor plan showing the size of the closet you will get more help. I assume this is a work office not just for home use .

The hamper can be moved. So, I don’t want to fixate in that one aspect.

I think the main issue is the workspace. I want to replace those 2 separate pieces with something that serves the same purpose with a smaller footprint and replace that folding chair with a proper ergonomic office chair.

The slider opens from the right. The control is on the left just so it’s more convenient to open and close while sitting on the bed. The actual slider glass isn’t opened as closed nearly as often as the sliding panels.

The Windows desktop is required because there is a need to run multiple Windows virtual machines for training purposes. I can replace that tower with a Windows PC similar in size into a Mac Mini and mount it behind the TV if needed, but I still need a keyboard/mouse tray that’s at a lower height than the main desk surface.

No need to access the PC remotely and have to walk to another area to turn it on and off if it can just be hidden behind a flat screen TV in arm’s reach of where you would be sitting.

While a lot of people buy desks from home furnishing companies for their home offices, it sounds like you need to visit an office furniture store, or look into the online offerings. Real office furniture will probably have some more practical aspects that you can use. I bought real office furniture 30 years ago, a solid oak desk and crendenza, and I still use them. They're not the peak of fashion anymore, but they are still in excellent condition and do the job. Office furniture manufacturers don't ignore style, so you really should be able to find something you like.

Buy a twin or twin-xl bed and place it along the wall, lengthwise. Slide two underbed storage bins under it as laundry hampers. Hang up the ironing board.

Buy a standard computer desk, 30 x 60 inches in size. It will have a fold down keyboard drawer and regular drawers you can stick the Mac in.

Buy whatever laptop PC you want- it will connect with the monitor.

Buy the good ergonomic chair you want.