These are the 2 moldings. Same design different size

Keep all casing the same dimension. What type of base are you using? What style doors? Trim getting painted? Doors and windows painted or stained? What does the interior of the home look like (inspo pics)?

Here is the base and crown i will be using. The doors are 2 panel raised. All trim and doors will be painted white.

nothing wrong with trim touching other trim.

I like your millwork option.

any good finish carpenter can trim doors and windows to look beautiful... often it IS the trim that makes the space. I vote for bigger rather than smaller.

Im just personally not a fan trim touching. Thats why i opted for the 2-1/2 for the doors. I thought the bigger casing around the window in the profile would look nice and pop with the picture frame style and inside mount cellular shades.