It is what it is. Once the room has furniture, art or TV hung above, and nice objects on the shelves, it won't be as obvious and won't bother you as much.

I'm curious if painting the baseboard to the left of the fireplace the same color as the wall would make it less obvious.

^ agree, even a taller/narrow plant there after the room is furnished could help

Take the shelves down wall hang a huge TV at the proper viewing on an articulating arm if needed and done Nice piece of art above the FP

Have a really, really, really nice rug.

And great art, not from an art fair, from a gallery, a great gallery.

It may help to walk around the house with your head constantly tilted slightly to the right, especially when guests are over.

What’s the floor plan? Is it actually off centre of where you would place the furniture?

@Patricia Colwell Consulting 's idea is a good one. You don't even have to get a gigantic TV to fill the entire space. You can have whatever size TV you want.

It would just be a much more pleasant view of this room if the TV were recessed and a nice piece of art were hanging above the fireplace. It would also focus your eye up on the art and distract you from noticing the off center placement of the fireplace. With just a black hole of a TV above the fireplace, you are going to notice the offcentered-ness more.

Without seeing the rest of the room we cannot advise on the furniture arrangement.

Yep! The fireplace is not centered.

1. Ignore it.
2. Pick a wall paint color to match the fireplace. So that it’s not so noticeable.
3. Move the eye up with some great art work.
4. Not much else you can do, except to start over🤷‍♀️

Me? I would embrace it. 😁

The way to make an asymmetical piece look intentional is to play up the assymetry. I'd style it with a tall thing on the right and a short thing on the left.

While this fireplace is symmetrical, the placement of the candles and the flowers lend them selves well to disguising assymetry.

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There's a 2x4 framing the door so the firebox can't be any closer. Move on.

Do not look for symmetry, look for balance. The image you post looks well engineered but poorly designed. If this is a custom design, you got screwed. The designer should be taken out and flogged.

To cure the current obstrocity look to decorate the floor, walls, shelves with beautiful distractions in hopes that it will conceal the poor design that has been bestowed upon you.

Do you plan to put the TV on this wall? I agree once there is furniture, art etc. in the room it will not stick out as much. I like Bev's first mock up with the TV over the cabinets to draw the eye in that direction.

You’re staring at an empty room and your brain is demanding symmetry which is impossible because of the architecture. But you can, with decoration, install objects that will satisfy your brain’s needs if you tackle each of the spaces independently of each other. Meaning, the fireplace just by itself, ignore the wall, hang whatever above it centered on the firebox. Ditto with the shelves. Give your eyes something symmetrical to look at in what will always be a large unsymmetrical wall.

Will suggest that you enlarge the door opening to the left of the fireplace. It shouldn't be very expensive. Should only involve a bit of framing and gyp. board work.

What kind of room is this since I see a door? Most living areas do not have doors to close them off? A more casual setting? Rec room? Bed room?

I do like the TV above the cabinets idea.

With the fireplace not being centered on the wall protrusion (and baseboard making it feel even more so), along with the entire wall feeling so broken up:

I’d fool the eye by painting the entire room, including baseboards, fireplace surround and cabinets/shelving all the same color. The richer the color, the more impactful and inviting the room would feel and the wall’s configuration will be a thing of the past. Two birds with one stone!

Remove your fireplace surround and add a narrow firewood niche.

Put molding around the doorway next to the fireplace to frame the doorway. That will make the fireplace look more centered on the wall and take away some space on the left.