@3onthetree Thanks. Even if the lines are coming from crawl space, I do not have to worry about "fire stopping" penetrations?

Call it "draft stop" rather than "fire stop." The material to block drafts does not have to be fire rated material. A local inspector might like to see the reddish foam/caulk, but it is not called for in base code for single family dwellings.

Thanks @3onthetree the only reason I have been thinking twice is because of the electrical conduit.

I purchased Gardner Bender duct seal compound so I will go ahead and use that!

you might not want to put any sealant around the open pipe shown by your smaller lefthand arrow on the bottom, it looks like it might be a condensate drain for an A/C evaporator. Blocking that could cause the pan to overflow.

Ask yourself "If I were a rat, could I chew through this?"