I think if you provide a little more info you will get some good ideas. For example, were is the current toilet, and where are the current drains for shower/tub and sinks? Are you considering moving the plumbing around, and if so, what kind of foundation do you have?

Thanks for the suggestions and response. Attached the current layout. There is an oversized large standalone tub taking up the entire left section of the room on an angle. A small sink (rectangle) on the top wall with the toilet beside it to the right. The bottom right corner was a small standup plastic shower. It’s all been demolished but gives you an idea where the current plumbing is. We have no problem to move the plumbing around and have full easy access to it from the unfinished basement underneath.

Here old photos

First, would definitely not use/add a free standing tub.

Either buy or create a tub shower combination to put that in the 5' long indent with the faucet in the wall by the door to the room because that ensures more elbow room for a right handed person standing in the tub/shower facing the faucet.

Then put the toilet -- choose a mid height rather than short one -- by the window at the end of the tub with its back against the same wall as the tub so you'll have a tub/shower wall partially blocking the view of toilet and give you a place to hang a safety rod and/or build in a niche for toilet paper holder into that wall just above toilet seat height. Create as much storage above toilet seat height in that wall as is practical such as for a toilet brush in a stand and a plunger and extra toilet tissue.

Then, provided it is in good condition and still usable, add your pedestal sink directly across from and centered with the toilet with a medicine cabinet with mirror centered over that.

Then, in lieu of a side vanity for the sink, add an alternative: between the pedestal sink and the door, add a shallow built in cabinet beneath that ?window? height? -- think stock tall overhead kitchen cabinet with shelves and doors -- but add a countertop atop it. Add a door stop the hinge of the door or to the floor or a wall (door knob) protector for the wall behind the door.

What about something like this?

Put beautiful tile in the tub area and 2 sided glass. The laundry will be behind bifold doors and you can have a nice storage space as well .

Good Luck!