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You have to layout the pattern very carefully. This tile is 12" x 11" You can't just way you want the insert 2 x 5 and expect this to work. The tile should be centerd in the insert. In order to not end up with slivers of cut tile, you might have to make the insert 26" x 62"

The 12 x 24 tile will likely not be all full tiles.

Sometimes it's easier to run these floral tile patterns from wall to wall instead of doing an insert. see example below.

Question - is your photo posted upside down? It sounds like you are referring to the tile on the bottom of the photo as tile #1 - or is the photo actually posted with tile #1 at the top of the photo?

The top mosaic tile in the photo you posted is this mosaic that is made out of recycled glass and mother of pearl:

The glass has been made to look like genuine marble = they added veining to different pieces in the mosaic in order to have the tile look like it has the variation of natural marble.

Is that what you don't like - or is it the real variation that the bottom water jet marble mosaic tile has?

The marble in this flower mosaic tile has quite a few pieces that have a darker gray shade. When you have natural stone installed, you need to have an installer who understands how to blend the different sheets of mosaic tile in order to not have areas that have a lot of darker pieces or areas that have a lot of whiter (lighter) pieces. Sometimes the installer has to actually remove pieces from the mesh sheet and exchange them with other pieces on other mosaic sheets in order to spread the different color variation throughout the installed area.

Beverly is correct about the size of the insert - the size has to be based upon the mosaic that you select. While the sheets may be similar in size, the pattern is larger on some sheets. You need to use enough sheets of the mosaic in order to have the insert look nice.

For example, in the photo below, the third mosaic tile (in your photo) has been installed as an insert in a shower:

It appears that 12" x 24" tiles have been used for the rest of the shower walls. Based upon a quick calculation (it's almost 1 a.m. - and I'm tired - hopefully, it's correct!) - the insert above is 42" W x 64" H. You would like to do a 24" x 60" insert. 3.5' x 5.33' vs. 2' x 5'. If you use the photo above and edit it in order to make the insert 2' x 5', you will be able to see what this particular mosaic will look like in a 10 sf insert. It seems like it may still look fine if you simply took 18" (1 1/2) tiles off of the width + 4" off the length (1/6th of the length of a tile).

I'm not sure how the first two would look in a 2' x 5' insert. You'd need a mock up of the tiles in an insert made by someone (Idk how to do that).

If you asked me about whether you should add a vertical strip of accent tile to your shower wall, I would say "no" - it seems like that look isn't really being done anymore. However, a "strip" of a water jet mosaic tile that runs from the ceiling to the floor (= 2' x 7') might look nice - I'd really need to see it to decide.

Framed inserts are a bit dated (I hate that word). I would try to avoid using pencil trim tiles for the frame. Depending on whether your style is traditional vs. transitional, the way you frame the insert will have a big impace on whether the insert looks more traditional or if it looks transitional by using a more modern type of frame. I recently posted some examples of different ways to frame the outside of a shower + a niche for someone - the "frames" were more contemporary than simply using a 1/2" pencil trim tile.

FYI - you can't calculate the amount of tile you will need just based upon the size of the insert. The tile for a 2' x5' insert does not mean that you need 10 sf of tile + another 10% of overage - you will need more than the typical 10% of extra tile. An insert (or walls) made out of these types of water jet mosaic tiles is completely different than when calculating how much tile you need if the mosaic tile being used was made out of something like 2" x 2" marble squares.

If you decide that you prefer how the mosaic tile would look if it is installed from the ceiling to the floor (instead of as a framed insert), the area will be 14 sf vs. 10 sf (not the amount of tile needed - just the area that will be covered with the water jet mosaic tile). You will be covering half of the wall with the mosaic tile - and have 1/4 of the wall on each side covered with your field tile. You really need to see a "mock up" of how this will look before you make a decision.

For everyone else, here's what the middle mosaic tile looks like when installed:

It is dolomite and mother of pearl used to make the mosaic. I bet it looks pretty in person.

I am in the keep it simple camp for bathrooms. I use a simple 12 x24 porcelain tile in a color I like and use it for bathroom floor , shwer walls and the same one only smaller for shower floor I choose a nice counter material for the accent and then I have an open choice for wall colr and accessories and the ability to change those when I want . Busty tile in small spaces is usually the first thing you come to hate.