I put two pulls on all my drawers > 27" and one pull on the narrower ones -- all pulls are the same size. Even though I often open them with one hand, they are rarely misaligned. Even when one does get out of alignment (it's happened only a couple of times in 11 years), all I had to do was pull them all the way out and wiggle them and they popped back into alignment. The first time I took the drawers off the glides (easy to do with Blum glides) and popped them back on...but the "wiggle" approach works just as well!

Note: This probably only applies to good quality hardware. I don't think I would have done two pulls/drawer if I had builder-grade glides.

There is really no right or wrong answer so just use what looks good to you. On your layout I would use the 5 1/6" pull on the 18" end cabinets and the 6 5/16" single pull on all of the other drawers. On drawers and pullouts under 21" including the trash pullouts, I used the 5 1/6" pull. All other drawers I used a single 6 5/16" pull except under the range top where I used two pulls on the 48" drawers. I used the 8" pull on the DWs flanking the main sink because they are big enough to hold a folded dry dish towel. This is how we signal which DW is in use. This sizing guide might help.

http://theknobbery.com/cabinet-hardware-sizing-guide

@wilson853 Great sizing guide! Very helpful. Thanks!

If I did something like @wilson853 is suggesting, what would you all do for the 9" base pantry pullouts (BPP9) on either side of the rangetop? A knob like I am using on the uppers, the same d-shape pull as the base drawers but maybe a little smaller like 3 or 3 3/4", or the coordinating cup pull? Whereas the larger drawer pulls will be installed in the recessed panel space of the drawer front, this one will be installed on the top rail. I guess same will be true with the trash pullout and dishwasher panel. So maybe I do another d-shape pull and keep it consistent? Those cabinets are so narrow, I wonder if I treat it differently? Thanks!

These pullouts are 15" wide, but the space between the molding is narrow so I used a knob with a 5 1/6" pull. The left opens as a single unit. The right side is a potholder drawer with a pullout beneath, so I had to treat both sides the same.

A cabinet maker recommended to me that I put ONE PULL on even the widest drawer. He said that few people open drawers with two hands - they usually have something in one. And pulling from one side where there are two pulls, pulls the glides out of balance/place. I used the same 5 1/4 " pulls on ALL my cabinets and drawers!

I have multiple wide drawers. Dog cubby now has two big, deep drawers as well.

How about if there’s a few narrower drawers (12” W) just in a couple areas (one on each side of cooktop, one flanking each side of the seating area)?

Note: The rest of kitchen drawers vary in width of 18” (garbage & recycling pull out), 24” 30” and a bank of drawers each area 33” (we’re doing knobs on doors, pulls on drawers but this is our only dilemna - can we do one pull size on All drawers -eg., 5 1/16” -of the few sizes available in our selected pulls, or must we mix pull sizes, or lastly double up the beginning size- 3 3/4” on the wider drawers. Sigh. *The showroom person mentioned maybe put knobs on just the drawers that are 12” but we ponder if that might throw off the consistent visial flow. First-time dealing with this. No idea how complex it can get!