Are you looking at it for the floors or for a shower? For shower walls I would think OK, but for the floor I'd say probably not. I have a similar sized bathroom, so imagining large floor tiles in my space--no. We have small pinwheel tile on the floor.

I am helping my sister redo an entire house and the bathroom floor tile for average and small baths (she has 2 secondary baths to do) was one of the most difficult things to find. We would up using a wood look plank tile. I felt 18x18 was too large and there isn't much tile in 12x12 or similar sizes.

It can be done with a careful layout

The perceived issue with the smaller tile shown above would disappear if a matching grout had been chosen instead of a contrasting one. Scale is always important. Using over scaled materials does not make a room seem larger. It makes it feel crowded and cramped, which is entirely the opposite effect.

Badger, those look really good! I like the diagonal layout in your bath and the white tiles in you DD's bath.

I finally found a photo of our pinwheel tile.

Badgergal, your daughter's floor is stunning. If the OP is planning on a similar look tile, I think it DOES make the room look larger. The light colors helps, but it's very realistic.